Initiation of protein biosynthesis in eukaryotes
نویسندگان
چکیده
منابع مشابه
Initiation of protein synthesis in eukaryotes.
The study of the regulation of initiation of protein synthesis has recently gained momentum because of the established relationship between translation initiation, cell growth and tumorigenesis. Therefore much effort is devoted to the role of protein kinases which are activated in signal transduction cascades and which are responsible for the phosphorylation of a number of initiation factors. T...
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The objective of this chapter is to provide an overview of eukaryotic phospholipid biosynthesis at an advanced level. Phospholipids make up the essential milieu of cellular membranes and act as a barrier for entry of compounds into cells. Phospholipids also function as precursors of second messengers such as diacylglycerol (DG) and inositol1,4,5-P3 which is covered in Chapter 12. A third, and u...
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Ribosome recruitment to eukaryotic mRNAs is generally thought to occur by a scanning mechanism, whereby the 40S ribosomal subunit binds in the vicinity of the 5'cap structure of the mRNA and scans until an AUG codon is encountered in an appropriate sequence context. Study of the picornaviruses allowed the characterization of an alternative mechanism of translation initiation. Picornaviruses can...
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ژورنال
عنوان ژورنال: Biochemistry and Molecular Biology Education
سال: 2003
ISSN: 1470-8175,1539-3429
DOI: 10.1002/bmb.2003.494031060274